Pfizer, Inc. (NYSE:PFE) Storebrand Conference: Invest in the Future Conference June 16, 2022 5:40 AM ET
Company Participants
Mikael Dolsten – Chief Scientific Officer and President, Worldwide Research, Development & Medical
Question-and-Answer Session
Q – Unidentified Analyst
Take us back to the day, to the moment when you found out that the vaccine worked?
Mikael Dolsten
It was a very special moment. We were gathered, a small core team from the executive leadership of Pfizer and our CEO, Albert Bourla. And it was the moment after such a long journey from March to the fall to look at whether the vaccine data would emerge favorable. It was like having been on a marathon race, but where every leg was a sprint. For those of you in Norway that are world class in skiing, I can only offer as an example the Swedish Vasaloppet, I’m sure you have Norwegian equivalent, but which is such a classical lengthy race. But imagine you needed to do every same piece of it with an absolute full speed, not keeping in mind that you are running for so many hours on the skis.
So after all that exhaustion, we were there on a web meeting that was to start and the question was will the vaccine work? How good would it be? It was a historical moment, because on one hand, if this vaccine wouldn’t work, I was hesitant that any of the ongoing vaccines would have a chance to work. And how would that affect all the people around the globe under this terrible fear of the pandemic?
So, you could hear the typical signal on the screen that it was opening up the Webex, and the voice from the team that had been working with the independent data monitoring committee to break the code and analyze the outcome suddenly broke up with a very positive facial expression and said, this was an extraordinary outcome of the trial that the vaccine had a great safety profile, works excellent and shared all the numbers that exceeded my expectation. So, I felt like I was flying up from the chair and more or less screaming, “Oh my God, it’s unbelievable”. It was probably the only moment in my professional career where I got so emotional and basically everyone in the room because it was appealing that this could save the world. And what an amazing thing to be part of doing what hasn’t been done in a century to come up something to contain a pandemic.
Unidentified Analyst
Let’s rewind to the beginning of 2020. Tell us about the journey from the moment you realized this was a pandemic and a vaccine was needed until the moment you knew you had the first successful vaccine.
Mikael Dolsten
Yes. From the reporting of the initial epidemic in China to it becoming increasingly replicated initially in Europe and some case in United States. It became increasingly clear that this was going to be a pandemic, whether small or large. And I acknowledged Albert Bourla, our CEO, who early on took the view that this is the moment when companies like we should rise to the challenge and use our resources, and see how we could make a difference. So Albert and I had many discussions on what we could contribute with. We started actually working on a pill. Some of you may now realize that that pill became PAXLOVID. The second big win, particularly playing a very large role in United States in containing terrible outcome still of the pandemic, but what became our moon shot was the vaccine work. And I would say the moment that really made us mobilize those resources was catalyzed by a call to action by the White House where I was representing Pfizer with another 10 companies, the key science and political leaders under the Trump administration, including the President and the VP where there and asking maybe the 10 leading companies in this area what they could do, what were their options. And it just felt historical having been in that room where so many decisions that would affect big things on our planet had been made.
Returning after that back to New York, talked to Albert, our CEO, and we realized that we should not just do the pill, it was time to also see if we contribute with a vaccine, and that we should explore with the German company BioNTech, if that technology could be useful. And that was the turn on button for that tremendous journey, run from March surpassing basically everyone else that was in this race, because I would say the tremendous team we mobilized that were so dedicated, and the willingness of Pfizer to put tremendous resources at bear. And I should say, not just human resources, capital resources, billions of dollars at risk without knowing first, if it would succeed.
So for me, this was an amazing experience of public-private partnership and where the private industry showed why it is so important and how we could play that instrumental role. And of course, I’m proud of being part of this team of our company, being a physician, and even having learned science and medicine in Scandinavia.
Unidentified Analyst
What made it possible to develop the vaccine in such — in a much shorter time than usual?
Mikael Dolsten
I think we often are defined by the experience we come with. We have a lot of biases. And we were actually trained originally in being aware of biases. Actually, there was a Nobel Prize winning economics, Daniel Kahneman at Princeton that we worked with for quite some time to be aware of biases. And one bias is not to be over optimistic about things. So, we actually moved four different vaccine formats in parallel, not to lose time if one didn’t work out, and then restarting. That was something that, I thought was very intriguing. That was to put a date when we need to be ready with this vaccine rather than traditionally saying how much time does each of the leg take. So, we put the date in fall that we needed it in October, because we know when it gets a cold season, that’s typically when viruses flourish inside and you could see maybe not just COVID, flu, and other viruses. And that would be a tremendous difficulty.
And then, we basically just gave each leg a certain time point. So for sub teams and entire team it could seem impossible. The key here was not to do as we did in the past, but to think outside the box, and try to do things differently and to do things in parallel, assuming success in the first step. And, of course, always make sure you build quality into the process that you feel nothing needs to be starting over again and that you would be able to describe a very safe and robust process.
So, this was an extraordinary way of working, and it just seemed to have been the right approach for this pandemic, driven by new technology. And hopefully, we can apply this approach into many other new areas, and be able to break down barriers that stand in the way of other medical breakthroughs.
Unidentified Analyst
I understand that they were both, cooperation and competition between Pfizer and the other vaccine developers. How important was this synergy to find a good solution? And do you think this can be a way to find solutions in other situations, like the climate crisis?
Mikael Dolsten
This is a great question and something I’ve been very fond of. We have been given an opportunity actually earlier in the United States to work together with NIH director, bringing together many companies. And I’ve shared some of those initiatives in how we tackle Alzheimer, diabetes, immune diseases to cancer moon shot we had in United States. So, we had a preparedness that when you collaborate, you can compete with, in this case, beating the virus much faster. Everyone is moving faster rather than not sharing, not collaborating and everyone moved slower. So, I got the call, I still remember today from the director of NIH, to me and asking, do you think the approach we’ve used before would also be suitable in COVID? And I said, absolutely. It will be a way for everyone to be able to move faster.
And we’re thinking ahead of the discussion with you Norwegians. It’s like you are out on one of your many great ski races and you were unable to prepare the bottom of the ski where you put on — I think it’s called [indiscernible] in Swedish region, this surface that is prepared to move very smooth on the snow. So, if you didn’t collaborate to have those great surfaces and everyone would be moving in the snow with a lot of friction, nobody would in the end have a great race.
So, this was a very transparent sharing of data that unlocked opportunity to move so fast and was just a tremendous way. And for us also, it showed that we could benefit by sharing rather than not sharing.
Unidentified Analyst
Thank you very much for joining us.
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